Thrombin generation and fibrin formation under flow on biomimetic tissue factor-rich surfaces.

@article{OnasogaJarvis2014ThrombinGA,
  title={Thrombin generation and fibrin formation under flow on biomimetic tissue factor-rich surfaces.},
  author={Abimbola A. Onasoga-Jarvis and T J Puls and Siobhan K. O'Brien and Liangju Kuang and Hou Jiun Liang and Keith B. Neeves},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2014},
  volume={12 3},
  pages={373-82}
}
BACKGROUND Blood flow regulates coagulation and fibrin assembly by controlling the rate of transport of zymogens, enzymes and plasma proteins to and from the site of an injury. OBJECTIVE The objective of this work was to define the hemodynamic conditions under which fibrin can form under flow on tissue factor (TF)-rich substrates. METHODS TF-coated silica beads (~ 800 nm) were patterned into 18-85-μm spots. Normal pooled plasma and factors VIII, IX and XI deficient plasmas were perfused… CONTINUE READING