Thrombin enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts; possible involvement in the pathogenesis of preeclampsia.

@article{Zhao2012ThrombinES,
  title={Thrombin enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts; possible involvement in the pathogenesis of preeclampsia.},
  author={Yin Zhao and Kaori Koga and Yutaka Osuga and Miwako Nagai and Gentaro Izumi and Masashi Takamura and Miyuki Harada and Yasushi Hirota and Osamu Yoshino and Yuji Taketani},
  journal={Fertility and sterility},
  year={2012},
  volume={98 4},
  pages={917-21}
}
OBJECTIVE To investigate the possible impact of thrombin on soluble Fms-like tyrosine kinase 1 (sFlt-1) expression in trophoblasts. DESIGN Experimental. SETTING University hospital laboratory. INTERVENTIONS(S) A trophoblast cell line (HRT-8/SVneo) was treated with thrombin, protease-activated receptor 1 (PAR-1)-specific agonist SFLLERN, and thrombin antagonist PPACK. MAIN OUTCOME MEASURE(S) mRNA expression of sFlt-1, vascular endothelial growth factor (VEGF), and placental growth factor… CONTINUE READING
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