Thrombin enhances adhesion in pancreatic cancer in vitro through the activation of the thrombin receptor PAR 1.

@article{Rudroff2001ThrombinEA,
  title={Thrombin enhances adhesion in pancreatic cancer in vitro through the activation of the thrombin receptor PAR 1.},
  author={Claudia Rudroff and Susanne Striegler and M B Schilli and J{\"u}rgen S. Scheele},
  journal={European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology},
  year={2001},
  volume={27 5},
  pages={472-6}
}
BACKGROUND Thrombin, the central enzyme of the coagulation cascade, induces proliferation in different solid tumours. The effect is mainly mediated through the functional thrombin receptor PAR 1, a member of the G-protein coupled receptor family. The aim of this study was to assess the role of thrombin on adhesion of pancreatic cancer to extracellular matrix proteins and endothelial cells in vitro. MATERIALS AND METHODS The human pancreatic adenocarcinoma cell line MIA PaCa-2 was treated with… CONTINUE READING

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