Thrombin-elicited contractile responses of aortic smooth muscle.

@article{Walz1985ThrombinelicitedCR,
  title={Thrombin-elicited contractile responses of aortic smooth muscle.},
  author={Daniel A. Walz and Gibson F. Anderson and R E Ciaglowski and Milam Aiken and John W Fenton},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1985},
  volume={180 3},
  pages={518-26}
}
Human alpha-thrombin at physiologically relevant concentrations of 0.75 to 225 nM (0.01 to 22 clotting units/ml) caused rabbit thoracic aorta to slowly contract in isolated organ baths. Near maximum contractile tension (10% below the irreversible contraction caused by 22 units/ml) was slowly generated by 75 nM alpha-thrombin (8 units/ml) over 18 min and was… CONTINUE READING