Thrombin during cardiopulmonary bypass.

  title={Thrombin during cardiopulmonary bypass.},
  author={L. Henry Edmunds and Robert W. Colman},
  journal={The Annals of thoracic surgery},
  volume={82 6},
Cardiopulmonary bypass (CPB) ignites a massive defense reaction that stimulates all blood cells and five plasma protein systems to produce a myriad of vasoactive and cytotoxic substances, cell-signaling molecules, and upregulated cellular receptors. Thrombin is the key enzyme in the thrombotic portion of the defense reaction and is only partially suppressed by heparin. During CPB, thrombin is produced by both extrinsic and intrinsic coagulation pathways and activated platelets. The routine use… CONTINUE READING