Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution.

  title={Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution.},
  author={Rodrigo Macaya and Peter Schultze and F W Smith and James A. Roe and Juli Feigon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={90 8},
We have used two-dimensional 1H NMR spectroscopy to study the conformation of the thrombin-binding aptamer d(GGTTGGTGTGGTTGG) in solution. This is one of a series of thrombin-binding DNA aptamers with a consensus 15-base sequence that was recently isolated and shown to inhibit thrombin-catalyzed fibrin clot formation in vitro [Bock, L. C., Griffin, L. C., Latham, J. A., Vermaas, E. H. & Toole, J. J. (1992) Nature (London) 355, 564-566]. The oligonucleotide forms a unimolecular DNA quadruplex… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 169 extracted citations

Similar Papers

Loading similar papers…