Thrombin as procoagulant and anticoagulant

@inproceedings{Cera2007ThrombinAP,
  title={Thrombin as procoagulant and anticoagulant},
  author={Enrico Di Cera},
  year={2007}
}
Summary.  Thrombin is a Na+-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Binding of Na+ is the major driving force behind the procoagulant, prothrombotic and signaling functions of the enzyme, but is dispensable for cleavage of the anticoagulant protein C. This basic regulatory feature of thrombin has fostered the rational engineering of mutants with selectively compromised fibrinogen and PAR1 cleavage. The discovery of the Na+ effect on… CONTINUE READING

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