Thrombin and vascular inflammation

  title={Thrombin and vascular inflammation},
  author={M. Popovi{\'c} and K. Smiljani{\'c} and B. Dobutovi{\'c} and T. Syrovets and T. Simmet and Esma R. Isenovi{\'c}},
  journal={Molecular and Cellular Biochemistry},
  • M. Popović, K. Smiljanić, +3 authors Esma R. Isenović
  • Published 2011
  • Medicine
  • Molecular and Cellular Biochemistry
  • Vascular endothelium is a key regulator of homeostasis. In physiological conditions it mediates vascular dilatation, prevents platelet adhesion, and inhibits thrombin generation. However, endothelial dysfunction caused by physical injury of the vascular wall, for example during balloon angioplasty, acute or chronic inflammation, such as in atherothrombosis, creates a proinflammatory environment which supports leukocyte transmigration toward inflammatory sites. At the same time, the dysfunction… CONTINUE READING
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