Thrombin and vascular inflammation

  title={Thrombin and vascular inflammation},
  author={M. Popovi{\'c} and K. Smiljani{\'c} and B. Dobutovi{\'c} and T. Syrovets and T. Simmet and Esma R. Isenovi{\'c}},
  journal={Molecular and Cellular Biochemistry},
  • M. Popović, K. Smiljanić, +3 authors Esma R. Isenović
  • Published 2011
  • Medicine, Biology
  • Molecular and Cellular Biochemistry
  • Vascular endothelium is a key regulator of homeostasis. In physiological conditions it mediates vascular dilatation, prevents platelet adhesion, and inhibits thrombin generation. However, endothelial dysfunction caused by physical injury of the vascular wall, for example during balloon angioplasty, acute or chronic inflammation, such as in atherothrombosis, creates a proinflammatory environment which supports leukocyte transmigration toward inflammatory sites. At the same time, the dysfunction… CONTINUE READING

    Figures and Topics from this paper.

    Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases.
    • 164
    • PDF
    Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases.
    • 119
    • PDF
    The Role of Gap Junction-Mediated Endothelial Cell–Cell Interaction in the Crosstalk between Inflammation and Blood Coagulation
    • 17
    • Highly Influenced
    • PDF
    Role of thrombin in the pathogenesis of atherosclerosis
    • 8


    Publications referenced by this paper.
    Bidirectional Relation Between Inflammation and Coagulation
    • 680
    • Highly Influential
    Protease‐activated receptors in hemostasis, thrombosis and vascular biology
    • 865
    • Highly Influential
    Platelet functions beyond hemostasis
    • 393
    Inflammation, sepsis, and coagulation.
    • 258
    • PDF
    Blood-borne tissue factor: another view of thrombosis.
    • 966
    • PDF