Thrombin and platelet activation.

  title={Thrombin and platelet activation.},
  author={L. Brass},
  volume={124 3 Suppl},
  • L. Brass
  • Published 2003
  • Medicine
  • Chest
  • The accumulation of thrombin at sites of vascular injury provides one of the chief means for recruiting platelets into a growing hemostatic plug. Studies completed over the past 10 years show that platelet responses to thrombin are mediated by a subset of G protein-coupled receptors known as protease-activated receptors. These receptors are activated on cleavage by thrombin, initiating the intracellular signaling events needed to transform mobile, nonadhesive platelets into cells that can… CONTINUE READING
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