Thrombin and platelet activation.

@article{Brass2003ThrombinAP,
  title={Thrombin and platelet activation.},
  author={Lawrence F. Brass},
  journal={Chest},
  year={2003},
  volume={124 3 Suppl},
  pages={
          18S-25S
        }
}
  • L. Brass
  • Published 1 September 2003
  • Medicine
  • Chest
The accumulation of thrombin at sites of vascular injury provides one of the chief means for recruiting platelets into a growing hemostatic plug. Studies completed over the past 10 years show that platelet responses to thrombin are mediated by a subset of G protein-coupled receptors known as protease-activated receptors. These receptors are activated on cleavage by thrombin, initiating the intracellular signaling events needed to transform mobile, nonadhesive platelets into cells that can… Expand
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