Thrombin and platelet activation.

@article{Brass2003ThrombinAP,
  title={Thrombin and platelet activation.},
  author={L. Brass},
  journal={Chest},
  year={2003},
  volume={124 3 Suppl},
  pages={
          18S-25S
        }
}
  • L. Brass
  • Published 2003
  • Medicine
  • Chest
  • The accumulation of thrombin at sites of vascular injury provides one of the chief means for recruiting platelets into a growing hemostatic plug. Studies completed over the past 10 years show that platelet responses to thrombin are mediated by a subset of G protein-coupled receptors known as protease-activated receptors. These receptors are activated on cleavage by thrombin, initiating the intracellular signaling events needed to transform mobile, nonadhesive platelets into cells that can… CONTINUE READING
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    • 160
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    • 1
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    • 352
    • PDF
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    • C. Gachet
    • Medicine
    • Annual review of pharmacology and toxicology
    • 2006
    • 270
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    References

    SHOWING 1-10 OF 56 REFERENCES
    A dual thrombin receptor system for platelet activation
    • 926
    Signaling through Gi Family Members in Platelets
    • 141
    • PDF
    Inhibition of platelet function by recombinant soluble ecto-ADPase/CD39.
    • 184
    • PDF