Thrombin and activated protein C inhibit the expression of secretory group IIA phospholipase A(2) in the TNF-alpha-activated endothelial cells by EPCR and PAR-1 dependent mechanisms.

@article{Bae2010ThrombinAA,
  title={Thrombin and activated protein C inhibit the expression of secretory group IIA phospholipase A(2) in the TNF-alpha-activated endothelial cells by EPCR and PAR-1 dependent mechanisms.},
  author={Jong-Sup Bae and Alireza R Rezaie},
  journal={Thrombosis research},
  year={2010},
  volume={125 1},
  pages={e9-e15}
}
INTRODUCTION Thrombin and tumor necrosis factor (TNF)-alpha up-regulate the expression of proinflammatory molecules in human umbilical vein endothelial cells (HUVECs). However, activated protein C (APC) down-regulates the expression of the same molecules. The expression level of secretory group IIA phospholipase A(2) (sPLA(2)-IIA) is known to be elevated in inflammatory disorders including in sepsis. Here, we investigated the effects of APC and thrombin on the expression of sPLA(2)-IIA and… CONTINUE READING

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Concentrationdependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 Kinase

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