Thrombin and Collagen Induce a Feedback Inhibitory Signaling Pathway in Platelets Involving Dissociation of the Catalytic Subunit of Protein Kinase A from an NFκB-IκB Complex*

@article{Gambaryan2010ThrombinAC,
  title={Thrombin and Collagen Induce a Feedback Inhibitory Signaling Pathway in Platelets Involving Dissociation of the Catalytic Subunit of Protein Kinase A from an NF$\kappa$B-I$\kappa$B Complex*},
  author={S. Gambaryan and A. Kobsar and N. Rukoyatkina and S. Herterich and J. Geiger and A. Smolenski and S. Lohmann and U. Walter},
  journal={The Journal of Biological Chemistry},
  year={2010},
  volume={285},
  pages={18352 - 18363}
}
Protein kinase A (PKA) activation by cAMP phosphorylates multiple target proteins in numerous platelet inhibitory pathways that have a very important role in maintaining circulating platelets in a resting state. Here we show that in thrombin- and collagen-stimulated platelets, PKA is activated by cAMP-independent mechanisms involving dissociation of the catalytic subunit of PKA (PKAc) from an NFκB-IκBα-PKAc complex. We demonstrate mRNA and protein expression for most of the NFκB family members… Expand
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