Thrombin Receptor Antagonists for the Treatment of Atherothrombosis

  title={Thrombin Receptor Antagonists for the Treatment of Atherothrombosis},
  author={Sergio Leonardi and Pierluigi Tricoci and Dr Richard C. Becker},
Platelet activation, achieved through a variety of surface receptors and biochemical mediators, represents a key event in the pathogenesis of atherothrombosis and its clinical manifestations. The major pathways involved in platelet activation are triggered by thromboxane A2, adenosine diphosphate and thrombin, with the latter being the most potent of these agonists. Despite the effective inhibition of the first two pathways with aspirin and several generations of P2Y12 receptor antagonists… CONTINUE READING
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Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1

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