Thrombin‐inhibiting perfluorocarbon nanoparticles provide a novel strategy for the treatment and magnetic resonance imaging of acute thrombosis

  title={Thrombin‐inhibiting perfluorocarbon nanoparticles provide a novel strategy for the treatment and magnetic resonance imaging of acute thrombosis},
  author={J. Myerson and L. He and G. Lanza and D. Tollefsen and S. Wickline},
  journal={Journal of Thrombosis and Haemostasis},
  • J. Myerson, L. He, +2 authors S. Wickline
  • Published 2011
  • Chemistry, Medicine
  • Journal of Thrombosis and Haemostasis
  • Summary.  Background: As a regulator of the penultimate step in the coagulation cascade, thrombin represents a principal target of direct and specific anticoagulants. Objective: A potent thrombin inhibitor complexed with a colloidal nanoparticle was devised as a first‐in‐class anticoagulant with prolonged and highly localized therapeutic impact conferred by its multivalent thrombin‐absorbing particle surface. Methods: PPACK (Phe[D]‐Pro‐Arg‐Chloromethylketone) was secured covalently to the… CONTINUE READING
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