Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats.

  title={Threshold size for optimal passive pulmonary targeting and retention of rigid microparticles in rats.},
  author={Hilliard L. Kutscher and Piyun Chao and Manjeet Deshmukh and Yashveer Singh and Peidi Hu and Laurie B. Joseph and David C. Reimer and Stanley Stein and Debra L. Laskin and Patrick J. Sinko},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={143 1},
The relationship between microparticle (MP) size and lung targeting efficiency, intra-lung distribution and retention time was systematically studied after intravenous administration of rigid fluorescent polystyrene MPs of various sizes (2, 3, 6 and 10 microm) to Sprague Dawley rats. Total fluorescence was assessed and it was found that 2 microm and 3 microm MPs readily passed through the lung to the liver and spleen while 10 microm MPs were completely entrapped in the lung for the one-week… CONTINUE READING


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