Threshold dose of piperonyl butoxide that induces reactive oxygen species-mediated hepatocarcinogenesis in rats

@article{Muguruma2008ThresholdDO,
  title={Threshold dose of piperonyl butoxide that induces reactive oxygen species-mediated hepatocarcinogenesis in rats},
  author={Masako Muguruma and Masaomi Kawai and Yasuaki Dewa and Jihei Nishimura and Yukie Saegusa and Hironobu Yasuno and Meilan Jin and Sayaka Matsumoto and Masayoshi Takabatake and Katsuhiko Arai and Kunitoshi Mitsumori},
  journal={Archives of Toxicology},
  year={2008},
  volume={83},
  pages={183-193}
}
To determine the threshold dose of piperonyl butoxide (PBO) that induces hepatocellular tumor-promoting effects, reactive oxygen species (ROS) generation, and drug-metabolizing enzymes that protect against ROS generation, partial hepatectomized rats were fed diets containing 0, 0.015, 0.03, 0.06, 0.125, 0.25, or 0.5% PBO after an i.p. injection of N-diethylnitrosamine (DEN) to initiate hepatocarcinogenesis. Histopathologically, Glutathione S-transferase placental form (GST-P)-positive foci were… CONTINUE READING

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Characterization of inducible nature of MRP3 in rat liver.

American journal of physiology. Gastrointestinal and liver physiology • 2000
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