Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries. A new mechanism of vasospasm?

@article{Yang1990ThresholdCO,
  title={Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries. A new mechanism of vasospasm?},
  author={Z. H. Yang and Vincent Richard and Ludvig K von Segesser and Erwin Bauer and Peter Stulz and Marko Turina and Thomas Felix L{\"u}scher},
  journal={Circulation},
  year={1990},
  volume={82 1},
  pages={
          188-95
        }
}
Endothelin-1 is an endothelium-derived vasoconstrictor peptide. Its circulating levels are below those known to evoke direct vascular effects. To study whether low concentrations of endothelin-1 potentiate the effects of other vasoconstrictor hormones, we suspended isolated human internal mammary and left anterior descending coronary artery rings in organ chambers for isometric tension recording. In mammary artery rings, the contractions to norepinephrine (3 x 10(-8) M) were potentiated by… CONTINUE READING
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