Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation.

@article{Soubeyrand2003Threonines2I,
  title={Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation.},
  author={S{\'e}bastien Soubeyrand and Louise J Pope and Benjamin Pakuts and R. J. Hache},
  journal={Cancer research},
  year={2003},
  volume={63 6},
  pages={1198-201}
}
DNA-dependent protein kinase (DNA-PK) is required for the repair of double-stranded DNA breaks through the nonhomologous DNA end joining pathway. DNA-PK activity is required for DNA repair, but kinase activity also appears to be attenuated through an autoregulatory feedback loop. We show that autophosphorylation of DNA-PK catalytic subunit occurs in trans at least three sites NH(2) terminal to the catalytic domain and that two sites, threonine 2638 and 2647, determine DNA-PK autophosphorylation… CONTINUE READING