Threonine phosphorylations induced by RX-871024 and insulin secretagogues in betaTC6-F7 cells.

@article{An1999ThreoninePI,
  title={Threonine phosphorylations induced by RX-871024 and insulin secretagogues in betaTC6-F7 cells.},
  author={J. An and G. Zhao and L. Churgay and J. Osborne and J. Hale and G. Becker and G. Gold and L. Stramm and Y. Shi},
  journal={The American journal of physiology},
  year={1999},
  volume={277 5},
  pages={
          E862-9
        }
}
  • J. An, G. Zhao, +6 authors Y. Shi
  • Published 1999
  • Biology, Medicine
  • The American journal of physiology
Treatment of the pancreatic beta-cell line betaTC6-F7 with an imidazoline compound, RX-871024, KCl, or tolbutamide resulted in increased threonine phosphorylation of a 220-kDa protein (p220) concurrent with enhanced insulin secretion, which can be partially antagonized by diazoxide, an ATP-sensitive potassium (K(ATP)) channel activator. Although phosphorylation of p220 was regulated by cytoplasmic free calcium concentration ([Ca(2+)](i)), membrane depolarization alone was not sufficient to… Expand
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