Threonine phosphorylations induced by RX-871024 and insulin secretagogues in βTC6-F7 cells.

@article{An1999ThreoninePI,
  title={Threonine phosphorylations induced by RX-871024 and insulin secretagogues in $\beta$TC6-F7 cells.},
  author={J. An and Genshi Zhao and L. Churgay and J. Osborne and J. Hale and G. Becker and G. Gold and L. Stramm and Y. Shi},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={1999},
  volume={277 5},
  pages={E862-E869}
}
  • J. An, Genshi Zhao, +6 authors Y. Shi
  • Published 1999
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
Treatment of the pancreatic β-cell line βTC6-F7 with an imidazoline compound, RX-871024, KCl, or tolbutamide resulted in increased threonine phosphorylation of a 220-kDa protein (p220) concurrent with enhanced insulin secretion, which can be partially antagonized by diazoxide, an ATP-sensitive potassium (KATP) channel activator. Although phosphorylation of p220 was regulated by cytoplasmic free calcium concentration ([Ca2+]i), membrane depolarization alone was not sufficient to induce… Expand
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References

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