Three-year Follow up of GMCSF/bi-shRNAfurin DNA-transfected Autologous Tumor Immunotherapy (Vigil) in Metastatic Advanced Ewing's Sarcoma.

@article{Ghisoli2016ThreeyearFU,
  title={Three-year Follow up of GMCSF/bi-shRNAfurin DNA-transfected Autologous Tumor Immunotherapy (Vigil) in Metastatic Advanced Ewing's Sarcoma.},
  author={Maurizio L. Ghisoli and Minal A Barve and Robert G. Mennel and Carl Lenarsky and Staci Horvath and Gladice Wallraven and Beena O. Pappen and Sam Whiting and Donald D. Rao and Neil N. Senzer and John Nemunaitis},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2016},
  volume={24 8},
  pages={1478-1483}
}
Ewing's sarcoma is a devastating rare pediatric cancer of the bone. Intense chemotherapy temporarily controls disease in most patients at presentation but has limited effect in patients with progressive or recurrent disease. We previously described preliminary results of a novel immunotherapy, FANG (Vigil) vaccine, in which 12 advanced stage Ewing's patients were safely treated and went on to achieve a predicted immune response (IFNγ ELISPOT). We describe follow-up through year 3 of a… CONTINUE READING

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