Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse.

@article{Nichol2007ThreeWO,
  title={Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse.},
  author={Kathryn E. Nichol and Anna I. Parachikova and Carl Cotman},
  journal={Behavioural brain research},
  year={2007},
  volume={184 2},
  pages={124-32}
}
If begun early in life, exercise effectively reduces the development of cognitive deficits in transgenic mouse models of Alzheimer's disease (AD). However, the effectiveness of exercise, once the cognitive impairments are established, is not as clear. In terms of translating research in animal models to treatments involving exercise in Alzheimer's disease patients, it is critical to evaluate exercise intervention at time points that address not only prevention, but also treatment of cognitive… CONTINUE READING