Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling.

@article{Patterson2009ThreeWO,
  title={Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling.},
  author={Christa M. Patterson and S{\'e}bastien Bouret and Ambrose A. Dunn-Meynell and Barry E. Levin},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2009},
  volume={296 3},
  pages={R537-48}
}
In rats selectively bred to develop diet-induced obesity (DIO) 3 wk of postweaning exercise reduces weight and adipose regain for 10 wk after exercise cessation, despite intake of 31% fat high-energy (HE) diet. To test the hypothesis that this effect is due to increased central leptin sensitivity, 4-wk-old DIO rats were fed the HE diet and left sedentary (Sed), exercised for 3 wk, and then remained sedentary for 10 additional weeks (Ex/Sed) or continued exercise for a full 13 wk (Ex). After 3… CONTINUE READING
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