Three time point changes in diffusion tensor values and their association with cognitive sequel among mild injury patients.

Abstract

AIM Diffusion tensor imaging (DTI) is an advanced and sensitive technique that detects sub--threshold pathology in normal imaging brain injury patients. Currently, there are no 3time--point studies that have considered DTI technique among these patients. The present study has investigated 3time--point DTI imaging and its association with cognitive deficits. METHODS Twenty--one patients were available for MRI and neuropsychological test (NPT) assessment for all the 3time-points. Initially (<36hours), all patients presented with GCS 15 and normal scan findings. The DTI (p<0.0001) and NPT scores (p<0.05) were analyzed using repeated--measure of analysis. The tensor values were correlated with specific time--point NPT scores using partial correlation (0.05). RESULTS Right cerebral--hemisphere showed significant alterations in both anisotropy and diffusivity values overtime. Cingulate--gyrus and occipital--lobe showed prominent changes in anisotropy value. Significant improvement in thalamo--cortical anisotropy value after 3--4months after injury was seen. The changes in diffusivity values were majorly seen in frontal, parietal lobe, right inferior fronto--occipital & superior longitudinal fasciculus, and posterior supramarginal gyrus. Eventual changes of tensor values of thalamus, frontal and temporal lobe had persistent and significant association with attention and learning/memory aspects. CONCLUSION The study's findings suggest that DTI detects and observes natural--recovery of brain regions affected by sub--threshold force.

Cite this paper

@article{Munivenkatappa2014ThreeTP, title={Three time point changes in diffusion tensor values and their association with cognitive sequel among mild injury patients.}, author={Ashok Munivenkatappa and Bhagavatula Indira Devi and Dhaval P Shukla and Jamuna Rajeswaran}, journal={Journal of neurosurgical sciences}, year={2014} }