Three-step model for condensin activation during mitotic chromosome condensation.

@article{Bazile2010ThreestepMF,
  title={Three-step model for condensin activation during mitotic chromosome condensation.},
  author={Franck Bazile and Julie St-Pierre and Damien D'Amours},
  journal={Cell cycle},
  year={2010},
  volume={9 16},
  pages={3243-55}
}
Chromosomes undergo a major structural reorganization during mitosis. The first step in this reorganization is the compaction of interphase chromatin into highly condensed mitotic chromosomes. An evolutionarily conserved multi-subunit ATPase, the condensin complex, plays a critical role in establishing chromosome architecture and promoting chromosome condensation in mitosis. How does condensin promote chromosome condensation and how, in turn, is the cell cycle machinery activating or… CONTINUE READING

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