Three sensitive assays do not provide evidence for circulating HuD-specific T cells in the blood of patients with paraneoplastic neurological syndromes with anti-Hu antibodies.

@article{Jongste2012ThreeSA,
  title={Three sensitive assays do not provide evidence for circulating HuD-specific T cells in the blood of patients with paraneoplastic neurological syndromes with anti-Hu antibodies.},
  author={Adriaan H C de Jongste and Marieke T. de Graaf and Emanuela Martinuzzi and Patricia D. M. van den Broek and J. K. Kraan and Cor H J Lamers and Roberto Mallone and Jan Willem C. Gratama and Peter A. E. Sillevis Smitt},
  journal={Neuro-oncology},
  year={2012},
  volume={14 7},
  pages={841-8}
}
Anti-Hu antibody-associated paraneoplastic neurological syndromes (Hu-PNSs) are severe and often precede the detection of a malignancy, usually small-cell lung cancer. In Hu-PNS, it is hypothesized that neuronal cells are destroyed by T cells targeted against HuD, a protein expressed by small-cell lung cancer cells and neurons. There is only limited… CONTINUE READING