Three roads to islet bursting: emergent oscillations in coupled phantom bursters.

Glucose-induced membrane potential and Ca(2+) oscillations in isolated pancreatic beta-cells occur over a wide range of frequencies, from >6/min (fast) to <1/min (slow). However, cells within intact islets generally oscillate with periods of 10-60 s (medium). The phantom bursting concept addresses how beta-cells can generate such a wide range of frequencies… CONTINUE READING