Three quaternary structures for a single protein.

  title={Three quaternary structures for a single protein.},
  author={Dading Huang and Clint Ainsworth and Fred J. Stevens and Marianne Schiffer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 14},
The structure of a multisubunit protein (immunoglobulin light chain) was solved in three crystal forms, differing only in the solvent of crystallization. The three structures were obtained at high ionic strength and low pH, high ionic strength and high pH, and low ionic strength and neutral pH. The three resulting "snapshots" of possible structures show that their variable-domain interactions differ, reflecting their stabilities under specific solvent conditions. In the three crystal forms, the… CONTINUE READING

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