Three potential susceptibility loci shown by a genome-wide scan for regions influencing the age at onset of mania.

OBJECTIVE The age at onset of bipolar disorder is associated with clinical features of the illness, including duration, severity, and pattern of comorbidity with other disorders. Age at onset is familial and heritable, and it correlates inversely with the prevalence of bipolar disorder among relatives. Because age at onset may have utility in resolving the… CONTINUE READING