• Corpus ID: 12079301

Three percent dietary fish oil concentrate increased efficacy of doxorubicin against MDA-MB 231 breast cancer xenografts.

  title={Three percent dietary fish oil concentrate increased efficacy of doxorubicin against MDA-MB 231 breast cancer xenografts.},
  author={W. Elaine Hardman and C. P. Reddy Avula and Gabriel Fernandes and Ivan L. Cameron},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={7 7},
  • W. HardmanC. P. Avula I. Cameron
  • Published 1 July 2001
  • Biology, Medicine, Chemistry
  • Clinical cancer research : an official journal of the American Association for Cancer Research
Omega 3 polyunsaturated fatty acids (the type of fat found in fish oil) have been used to kill or slow the growth of cancer cells in culture and in animal models and to increase the effectiveness of cancer chemotherapeutic drugs. An AIN-76 diet containing 5% corn oil (CO) was modified to contain 3% w/w fish oil concentrate (FOC) and 2% CO to test whether a clinically applicable amount of FOC is beneficial during doxorubicin (DOX) treatment of cancer xenografts in mice. Compared with the diet… 

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