Three percent diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses: a meta-analysis of the recent studies

@article{Pirard2005ThreePD,
  title={Three percent diclofenac in 2.5\% hyaluronan gel in the treatment of actinic keratoses: a meta-analysis of the recent studies},
  author={Delphine Pirard and Pierre Vereecken and Christian M{\'e}lot and Michel Heenen},
  journal={Archives of Dermatological Research},
  year={2005},
  volume={297},
  pages={185-189}
}
Three percent diclofenac in 2.5% hyaluronan gel (DHA) is approved by the Food and Drug Administration (FDA) in the treatment of actinic keratoses (AK). We conducted a meta-analysis of the few prospective studies that evaluated the effect of DHA on the target lesion number score TLNS0 (indicating complete resolution of all target lesions in the treatment area) and/or the cumulative target lesion number score CLNS0 (indicating resolution of the target and new lesions in the treatment area) with… 
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References

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Topical 3% Diclofenac in 2.5% Hyaluronic Acid Gel
TLDR
Diclofenac HA gel produces significant reductions in the number of AK lesions, and can produce complete clearance of lesions when applied twice daily for 60 or 90 days, and is well tolerated and did not produce serious adverse cosmetic effects in clinical trials.
Topical diclofenac/hyaluronic acid gel in the treatment of solar keratoses
A randomized double‐blind controlled trial of 130 patients was performed to study the efficacy and tolerability of topical 3% diclofenac in 2.5% hyaluronic acid (HA) gel (active) versus gel
Topical diclofenac in hyaluronan gel for the treatment of solar keratoses
TLDR
Topical 3% diclofenac in 2.5% hyaluronan gel was effective and well tolerated in this study, suggesting a role for this therapy in the treatment of SK.
An open study to assess the efficacy and safety of topical 3% diclofenac in a 2.5% hyaluronic acid gel for the treatment of actinic keratoses.
TLDR
Topical 3% diclofenac in 2.5% hyaluronic acid gel may be a clinically useful topical agent for the treatment of actinic keratoses.
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TLDR
The efficacy and tolerability of 3.0% diclofenac sodium gel in the treatment of actinic keratoses (AK) lesions was evaluated in patients diagnosed with five or more AK lesions contained in 1 to 3 blocks on the forehead, central face, or scalp and investigators' assessment based on Investigator Global Improvement Index confirmed the efficacy.
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TLDR
The results obtained by this study demonstrate that the topical application of an HA-containing preparation represents a potentially useful adjunct in the therapy of gingivitis, although its use does not diminish the need for plaque reduction as a primary therapeutic measure.
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Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis.
TLDR
HA is a useful and well-tolerated symptomatic treatment for knee osteoarthritis with a rapid onset of action and statistical differences were found when basal determinations of the three parameters were compared with the results of the first and fourth administration.
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TLDR
The physicochemical properties of HA, and the binding of HA to HA receptors, suggests that HA will have value as a novel drug delivery system.
Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin
  • Mb Brown, Sa Jones
  • Biology, Medicine
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2005
TLDR
A regulatory approval was granted recently for 3% diclofenac in 2.5% HA gel, Solaraze®, for the topical treatment of actinic keratoses, which is the third most common skin complaint in the USA.
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