Three paradoxes of ferric enterobactin uptake.

  title={Three paradoxes of ferric enterobactin uptake.},
  author={Phillip E Klebba},
  journal={Frontiers in bioscience : a journal and virtual library},
  • P. Klebba
  • Published 1 September 2003
  • Biology
  • Frontiers in bioscience : a journal and virtual library
Bacteria elaborate iron chelators that scavenge iron from the environment, including their human and animal hosts, and iron acquisition is a determinant of pathogenicity. One such iron chelate, the siderophore ferric enterobactin, enters Gram-negative bacteria through the FepA protein of the outer membrane. The ferric enterobactin transport process is a high-affinity, multi-specific, multi-component, energy dependent reaction, that is a paradigm of ligand-gated transport: FeEnt binding… 

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