Three pairs of cysteine residues mediate both redox and zn2+ modulation of the nmda receptor.

@article{Choi2001ThreePO,
  title={Three pairs of cysteine residues mediate both redox and zn2+ modulation of the nmda receptor.},
  author={Younggi Choi and H V Chen and Stuart Lipton},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 2},
  pages={392-400}
}
NMDA receptor activity is modulated by various compounds, including sulfhydryl redox agents and Zn(2+). In addition to a slow and persistent component of redox modulation common to all NMDA receptors, NR1/NR2A receptors uniquely have a rapid and reversible component that has been variously attributed to redox or Zn(2+) effects. Here we show that this rapid modulatory effect can be described by two time constants with relatively fast ( approximately 6 sec) and intermediate (60 sec) half lives… CONTINUE READING