Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases.

@article{Rao2004ThreeNM,
  title={Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases.},
  author={Karumanchi V. Rao and Noer Kasanah and Subagus Wahyuono and Babu L. Tekwani and Raymond F Schinazi and Mark T. Hamann},
  journal={Journal of natural products},
  year={2004},
  volume={67 8},
  pages={1314-8}
}
Three new manzamine-type alkaloids, 12,34-oxamanzamine E (3), 8-hydroxymanzamine J (4), and 6-hydroxymanzamine E (8), as well as 12 previously characterized manzamine alkaloids have been isolated from a common Indonesian sponge of the genus Acanthostrongylophora. The structures of the new compounds have been established on the basis of 1D and 2D NMR spectroscopic analysis and comparison of the data to literature values of related compounds. The biological activities and structure-activity… CONTINUE READING

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