Three myosin V structures delineate essential features of chemo-mechanical transduction.

@article{Coureux2004ThreeMV,
  title={Three myosin V structures delineate essential features of chemo-mechanical transduction.},
  author={Pierre-Damien Coureux and H Lee Sweeney and Anne Houdusse},
  journal={The EMBO journal},
  year={2004},
  volume={23 23},
  pages={4527-37}
}
The molecular motor, myosin, undergoes conformational changes in order to convert chemical energy into force production. Based on kinetic and structural considerations, we assert that three crystal forms of the myosin V motor delineate the conformational changes that myosin motors undergo upon detachment from actin. First, a motor domain structure demonstrates that nucleotide-free myosin V adopts a specific state (rigor-like) that is not influenced by crystal packing. A second structure reveals… CONTINUE READING

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