Three modes of ossification during distraction osteogenesis in the rat.

  title={Three modes of ossification during distraction osteogenesis in the rat.},
  author={Norihisa Yasui and Masahiko Sato and Takahiro Ochi and Tomoatsu Kimura and Hirohisa Kawahata and Yukihiko Kitamura and Shintaro Nomura},
  journal={The Journal of bone and joint surgery. British volume},
  volume={79 5},
We developed a rat model of limb lengthening to study the basic mechanism of distraction osteogenesis, using a small monolateral external fixator. In 11-week-old male rats we performed a subperiosteal osteotomy in the midshaft of the femur with distraction at 0.25 mm every 12 hours from seven days after operation. Radiological and histological examinations showed a growth zone of constant thickness in the middle of the lengthened segment, with formation of new bone at its proximal and distal… CONTINUE READING
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Method for detecting the expression of bone matrix protein by in situ hybridization using decalcified mineralised tissue

  • S Nomura, K Hirakawa, J Nagoshi
  • Acta Histochem Cytochem
  • 1993
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