Three mitochondrial transporters of Saccharomyces cerevisiae are essential for ammonium fixation and lysine biosynthesis in synthetic minimal medium.

@article{Scarcia2017ThreeMT,
  title={Three mitochondrial transporters of Saccharomyces cerevisiae are essential for ammonium fixation and lysine biosynthesis in synthetic minimal medium.},
  author={Pasquale Scarcia and Luigi Palmieri and Gennaro Agrimi and Ferdinando Palmieri and Hanspeter Rottensteiner},
  journal={Molecular genetics and metabolism},
  year={2017},
  volume={122 3},
  pages={
          54-60
        }
}
The nuclear genes of Saccharomyces cerevisiae YHM2, ODC1 and ODC2 encode three transporters that are localized in the inner mitochondrial membrane. In this study, the roles of YHM2, ODC1 and ODC2 in the assimilation of nitrogen and in the biosynthesis of lysine have been investigated. Both the odc1Δodc2Δ double knockout and the yhm2Δ mutant grew similarly as the YPH499 wild-type strain on synthetic minimal medium (SM) containing 2% glucose and ammonia as the main nitrogen source. In contrast… CONTINUE READING
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