Three minute, but not one minute, ischemia and nicorandil have a preconditioning effect in patients with coronary artery disease.

@article{Matsubara2000ThreeMB,
  title={Three minute, but not one minute, ischemia and nicorandil have a preconditioning effect in patients with coronary artery disease.},
  author={Tetsuo Matsubara and Shinya Minatoguchi and Hisayuki Matsuo and Katsumi Hayakawa and Tomonori Segawa and Yukihiko Matsuno and Satoshi Watanabe and Masazumi Arai and Yoshihiro Uno and Masanori Kawasaki and Takashi Noda and Genzou Takemura and Kazuhiko Nishigaki and Hisayoshi Fujiwara},
  journal={Journal of the American College of Cardiology},
  year={2000},
  volume={35 2},
  pages={345-51}
}
OBJECTIVES This study focused on 1) the determination of the optimal preconditioning (PC) duration, and 2) the protective effect of nicorandil (NC), a hybrid nitrate with a KATP channel opening effect, during a percutaneous transluminal coronary angioplasty (PTCA) model in humans. BACKGROUND The ischemic PC effect is induced in 180 s ischemia, but not in 120 s ischemia in rabbit hearts. However, the duration of ischemia that induces PC effect and the role of the KATP channel in the PC effect… CONTINUE READING

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Nicorandil induces late preconditioning against myocardial infarction in conscious rabbits.

American journal of physiology. Heart and circulatory physiology • 2004
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Vasodilator Therapy: Nitrates and Nicorandil

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