Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.

@article{Donkor2006ThreeML,
  title={Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns.},
  author={Jimmy Donkor and Meltem Sariahmetoglu and Jay W. Dewald and David N. Brindley and Karen Reue},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={282 6},
  pages={
          3450-7
        }
}
We previously identified mutations in the Lpin1 gene, encoding lipin-1, as the underlying cause of lipodystrophy in the fatty liver dystrophy (fld) mutant mouse. Lipin-1 is normally expressed at high levels in adipose tissue and skeletal muscle, and deficiency in the fld mouse causes impaired adipose tissue development, insulin resistance, and altered energy expenditure. We also identified two additional lipin protein family members of unknown function, lipin-2 and lipin-3. Han et al. (Han, G… CONTINUE READING
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