Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling.

@article{Barolo2002ThreeHO,
  title={Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signaling.},
  author={Scott Barolo and James W Posakony},
  journal={Genes & development},
  year={2002},
  volume={16 10},
  pages={1167-81}
}
Seven major cell–cell signaling pathways—Wnt, TGF, Hedgehog (Hh), receptor tyrosine kinase (RTK), nuclear receptor, Jak/STAT, and Notch—control the vast majority of cell fate decisions during the development of bilaterian animals (Gerhart 1999). Each pathway is used repeatedly during the development of a given organism, activating different subsets of target genes in different developmental contexts. These seven pathways are strikingly diverse in both their complexity and the biochemical… CONTINUE READING
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