Three fingers on the switch: Krüppel-like factor 1 regulation of γ-globin to β-globin gene switching.

  title={Three fingers on the switch: Kr{\"u}ppel-like factor 1 regulation of γ-globin to β-globin gene switching.},
  author={Michael R. Tallack and Andrew C. Perkins},
  journal={Current opinion in hematology},
  volume={20 3},
PURPOSE OF REVIEW Krüppel-like factor 1 (KLF1) regulates most aspects of erythropoiesis. Many years ago, transgenic mouse studies implicated KLF1 in the control of the human γ-globin to β-globin switch. In this review, we will integrate these initial studies with recent developments in human genetics to discuss our present understanding of how KLF1 and its target genes direct the switch. RECENT FINDINGS Recent studies have shown that human mutations in KLF1 are common and mostly asymptomatic… CONTINUE READING