Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples.

@article{Costa2010ThreeEB,
  title={Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples.},
  author={Vera L{\'u}cia Costa and Rui Henrique and Stine Aske Danielsen and Sara Duarte-Pereira and Mette Eknaes and Rolf I. Skotheim and Angelo Brito Rodrigues and Jose Ronaldo Magalhaes and Jorge Luiz Barcelos Oliveira and Ragnhild A. Lothe and Manuel R Teixeira and Carmen Jer{\'o}nimo and Guro E Lind},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2010},
  volume={16 23},
  pages={5842-51}
}
PURPOSE To identify a panel of epigenetic biomarkers for accurate bladder cancer (BlCa) detection in urine sediments. EXPERIMENTAL DESIGN Gene expression microarray analysis of BlCa cell lines treated with 5-aza-2'-deoxycytidine and trichostatin A as well as 26 tissue samples was used to identify a list of novel methylation candidates for BlCa. Methylation levels of candidate genes were quantified in 4 BlCa cell lines, 50 BlCa tissues, 20 normal bladder mucosas (NBM), and urine sediments from… CONTINUE READING