Three endothelial nitric oxide (NOS3) gene polymorphisms in hypertensive and normotensive individuals: meta-analysis of 53 studies reveals evidence of publication bias

@article{Pereira2007ThreeEN,
  title={Three endothelial nitric oxide (NOS3) gene polymorphisms in hypertensive and normotensive individuals: meta-analysis of 53 studies reveals evidence of publication bias},
  author={Tiago Veiga Pereira and Martin Rudnicki and Bernard Man-Yung Cheung and Larry Baum and Yoshiji Yamada and Paulo SL Oliveira and Alexandre da Costa Pereira and Jos{\'e} Eduardo Krieger},
  journal={Journal of Hypertension},
  year={2007},
  volume={25},
  pages={1763–1774}
}
Background Studies on the relationship between endothelial nitric oxide (NOS3) gene variants and hypertension have been conflicting. To explore this hypothesis further, we performed a meta-analysis and re-evaluated the relationship between the three most widely studied NOS3 polymorphisms and hypertension status and blood pressure levels. Methods Data on 40 413 subjects from 53 studies were combined in five distinct meta-analyses, and heterogeneity and publication bias were explored. Results… 

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The role of eNOS G894T and 4b/a polymorphisms on hypertension in Asians, and T−786C polymorphism in Whites is ascertained via a comprehensive meta-analysis.

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Results of cumulative and recursive cumulative meta-analysis indicated that more studies are needed to objectively determine the effects of these two polymorphisms, but there was no evidence for a significant association after the exclusion of two studies deviating from Hardy-Weinberg equilibrium in the control group.

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TLDR
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TLDR
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TLDR
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TLDR
Interaction between obesity and NOS3 genotype may be a determinant of diabetes case status in whites in the ARIC cohort, and significant interaction between BMI and the Nos3 polymorphism indicated that obesity was an effect modifier of diabetes risk for white individuals with the TT genotype.

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TLDR
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The interaction of AGT and NOS3 gene polymorphisms with conventional risk factors increases predisposition to hypertension

TLDR
Blood pressure homeostasis was affected by genetic polymorphisms conditioned by the T and A alleles of the AGT and NOS3 genes, respectively, which acted independently, however, their interaction with smoking, sedentariness, age and total cholesterol may have increased the predisposition to hypertension, which may explain most of the hypertension cases.

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TLDR
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Association of renin–angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study

TLDR
Blood pressure progression and incident hypertension are not consistently associated with six well-characterized genetic polymorphisms of the renin–angiotensin system and the NOS3 gene in a large cohort of Caucasian women.
...

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