Three-dimensional tumor models: Promoting breakthroughs in nanotheranostics translational research

@article{Mapanao2020ThreedimensionalTM,
  title={Three-dimensional tumor models: Promoting breakthroughs in nanotheranostics translational research},
  author={Ana Katrina Mapanao and Valerio Voliani},
  journal={Applied Materials Today},
  year={2020},
  volume={19},
  pages={100552}
}

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References

SHOWING 1-10 OF 214 REFERENCES

Multicellular Tumor Spheroids (MCTS) as a 3D In Vitro Evaluation Tool of Nanoparticles.

MCTS are suitable models to gain additional information on nanoparticles while not being able to replace in vivo studies, they can bridge the gap between traditional 2D in vitro studies and in vivo models.

Impact of multicellular tumor spheroids as an in vivo-like tumor model on anticancer drug response

Findings indicate that the method of drug encapsulation in liposomes may improve the treatment efficacy of chemotherapeutic agents.

3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained

The analyses, carried out using a novel open source software capable of performing an automatic image analysis of 3D tumor colonies, showed that a number of morphology parameters affect the response of large spheroidids to treatment and indicate the need for a pre-selection of tumor spheroids of homogeneous volume and shape before use in a cytotoxicity test.

Mechanisms and Barriers in Cancer Nanomedicine: Addressing Challenges, Looking for Solutions.

This Nano Focus presents the main discussion topics and conclusions from a recent workshop: "Mechanisms and Barriers in Nanomedicine", on biological, toxicological, immunological, and translational aspects of nanomedicines and approaches to move the field forward productively.

Incorporation of multicellular spheroids into 3‐D polymeric scaffolds provides an improved tumor model for screening anticancer drugs

A novel in vitro model in which multicellular aggregates, or spheroids, were incorporated into 3‐D porous scaffolds showed that spheroid‐seeded scaffolds have much higher drug resistance than monolayer cultures, spheroid cultures on flat substrates,or scaffolds seeded with dispersed cells.

Production of Uniform 3D Microtumors in Hydrogel Microwell Arrays for Measurement of Viability, Morphology, and Signaling Pathway Activation.

The hydrogel microwell array platform can be applied successfully to generate hundreds of uniform microtumors within 3-6 days from many cervical and breast, as well as head and neck squamous cell carcinoma (HNSCC) cells and is demonstrated to provide more physiological in vitro 3D tumor models to investigate how tumor size influences signaling pathway activation and cancer drug efficacy.

Liquid-based three-dimensional tumor models for cancer research and drug discovery

Different tumor models are described and a model known as tumor spheroid is focused on, which addresses the influence of stromal fibroblasts and immune cells on cancer cells in tumor microenvironment, study cancer stem cells, and facilitate compound screening in the drug discovery process.

Cancer tissue engineering - new perspectives in understanding the biology of solid tumours - a critical review

This critical review of three-dimensional biomimetic tumour models focuses upon interesting studies recently reported in the published literature about cancer TE, grouping their findings by tumour type, to give a snapshot picture of the current achievements to those cancer scientists, who are wishing to approach the field of TE.
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