Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of Down syndrome.

@article{Popov2011ThreedimensionalSU,
  title={Three-dimensional synaptic ultrastructure in the dentate gyrus and hippocampal area CA3 in the Ts65Dn mouse model of Down syndrome.},
  author={Victor I. Popov and Alexander Kleschevnikov and Oleg A. Klimenko and Michael G. Stewart and Pavel V. Belichenko},
  journal={The Journal of comparative neurology},
  year={2011},
  volume={519 7},
  pages={
          1338-54
        }
}
Down syndrome (DS) results from trisomy of human chromosome 21. Ts65Dn mice are an established model for DS and show several phenotypes similar to those in people with DS. However, there is little data on the structural plasticity of synapses in the trisynaptic pathway in the hippocampus. Here we investigate 3D ultrastructure of synapses in the hippocampus of age-matched control (2N) and Ts65Dn male mice. Serial ultrathin sections and 3D reconstructions characterize synapses in the middle… CONTINUE READING
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