Three-dimensional super-resolution and localization of dense clusters of single molecules

  title={Three-dimensional super-resolution and localization of dense clusters of single molecules},
  author={Anthony Barsic and Ginni Grover and Rafael Piestun},
  booktitle={Scientific reports},
When a single molecule is detected in a wide-field microscope, the image approximates the point spread function of the system. However, as the distribution of molecules becomes denser and their images begin to overlap, existing solutions to determine the number of molecules present and their precise three-dimensional locations can tolerate little to no overlap. We propose a localization scheme that can identify several overlapping molecule images while maintaining high localization precision. A… CONTINUE READING

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Super-resolution of dense nanoscale emitters beyond the diffraction limit using spatial and temporal information

  • A. Barsic, R. Piestun
  • Appl. Phys. Lett. 102,
  • 2013

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