Three-dimensional structures of HIV-1 and SIV protease product complexes.

@article{Rose1996ThreedimensionalSO,
  title={Three-dimensional structures of HIV-1 and SIV protease product complexes.},
  author={Robert B. Rose and Charles S. Craik and Nancy L. Douglas and Robert Michael Stroud},
  journal={Biochemistry},
  year={1996},
  volume={35 39},
  pages={
          12933-44
        }
}
Strain is eliminated as a factor in hydrolysis of the scissile peptide bond by human immunodeficiency virus (HIV)-1 and simian immunodeficiency virus (SIV), based on the first eight complexes of products of hydrolysis with the enzymes. The carboxyl group generated at the scissile bond interacts with both catalytic aspartic acids. The structures directly suggest the interactions of the gemdiol intermediate with the active site. Based on the structures, the nucleophilic water is displaced… CONTINUE READING

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