Three-dimensional structure of tropism-switching Bordetella bacteriophage.

  title={Three-dimensional structure of tropism-switching Bordetella bacteriophage.},
  author={Wei Dai and Asher Hodes and Wong Hoi Hui and Mari Gingery and Jeff Miller and Z. Hong Zhou},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 9},
Bacteriophage BPP-1, which infects Bordetella species, can switch its specificity by mutations to the ligand-binding surface of its major tropism-determinant protein, Mtd. This targeted mutagenesis results from the activity of a phage-encoded diversity-generating retroelement. Purified Mtd binds its receptor with low affinity, yet BPP-1 binding and infection of Bordettella cells are efficient because of high-avidity binding between phage-associated Mtd and its receptor. Here, using an… CONTINUE READING


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