Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography

@article{Liu2006ThreedimensionalSO,
  title={Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography},
  author={Jun Liu and Dianne W. Taylor and Elena B. Krementsova and Kathleen M Trybus and Kenneth A. Taylor},
  journal={Nature},
  year={2006},
  volume={442},
  pages={208-211}
}
Unconventional myosin V (myoV) is an actin-based molecular motor that has a key function in organelle and mRNA transport, as well as in membrane trafficking. MyoV was the first member of the myosin superfamily shown to be processive, meaning that a single motor protein can ‘walk’ hand-over-hand along an actin filament for many steps before detaching. Full-length myoV has a low actin-activated MgATPase activity at low [Ca2+], whereas expressed constructs lacking the cargo-binding domain have a… CONTINUE READING