Three-dimensional structure of the cytoplasmic face of the G protein receptor rhodopsin.

@article{Yeagle1997ThreedimensionalSO,
  title={Three-dimensional structure of the cytoplasmic face of the G protein receptor rhodopsin.},
  author={Philip L. Yeagle and James L. Alderfer and Arlene D. Albert},
  journal={Biochemistry},
  year={1997},
  volume={36 32},
  pages={9649-54}
}
Rhodopsin is a G protein receptor from a many-membered family of membrane receptors. No high-resolution structure exists for any member of this family due to the insolubility of membrane proteins and the difficulty in crystallizing membrane proteins. Two new approaches to the structure of rhodopsin are described that circumvent these limitations: (1) individual solution structures of the four cytoplasmic domains of rhodopsin are fitted with the transmembrane domain; (2) the solution structure… CONTINUE READING

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