Three-dimensional structure of the bifunctional enzyme N-(5'-phosphoribosyl)anthranilate isomerase-indole-3-glycerol-phosphate synthase from Escherichia coli.

Abstract

N-(5'-Phosphoribosyl)anthranilate isomerase-indole-3-glycerol-phosphate synthase from Escherichia coli is a monomeric bifunctional enzyme of Mr 49,500 that catalyzes two sequential reactions in the biosynthesis of tryptophan. The three-dimensional structure of the enzyme has been determined at 2.8-A resolution by x-ray crystallography. The two catalytic… (More)

Topics

Cite this paper

@article{Priestle1987ThreedimensionalSO, title={Three-dimensional structure of the bifunctional enzyme N-(5'-phosphoribosyl)anthranilate isomerase-indole-3-glycerol-phosphate synthase from Escherichia coli.}, author={John P. Priestle and Markus G. Gruetter and J. L. White and M G Vincent and Marek Kania and E. Wilson and Theodore S. Jardetzky and Kristi L. Kirschner and Johan N. Jansonius}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1987}, volume={84 16}, pages={5690-4} }